July 2017 Jimmy will give the Wellcome Centre Brain meeting on laminar inference with meg
Can we non-invasively resolve signals from different cortical layers in humans?
Recent computational, anatomical and physiological evidence suggests that feedforward signals tend to originate in supra-granular cortex and be of predominantly high-temporal frequency content (>30 Hz) whereas feedback signals tend to originate in infra-granular cortex and are characterized by slower dynamics (<30Hz). I will demonstrate that using new recording technology, it is now possible to make frequency-specific laminar inferences with magnetoencephalography (MEG) in a spatially localized and time-resolved manner, non-invasively and in vivo. I will describe global and local analyses for making laminar-specific inferences with MEG using parametric and non-parametric measures, and demonstrate their concordance in simulation. I will then present empirical evidence from a predictive action selection task which shows that spatially resolved laminar inferences of human sensorimotor and visual induced activity can be made using MEG, attributing low frequency (<30Hz) activity to infra-granular sources, and high frequency activity (>60Hz) to supra-granular sources. Finally I will discuss potential extensions of this technique to estimate the time course of laminar activity during evoked responses.
May 2017 Louise has passed her viva!
Big thanks to Emra Duzel and Hanneke den Ouden for examining Louise, who passed without corrections. Very proud and congratulations
June 2017 Sven and Jimmy will teach a neuroscience module at Tohoku University, Japan
Looking forward to go to Tohoku University in Japan soon, together with Jimmy Bonaiuito, enabled through the UCL Global Engagement Fund, to teach a module on action, decision making and neuroimaging
June 2017 New paper on methods for laminar-resolved MEG
Our new paper "Non-invasive laminar inference with MEG: Comparison of methods and source inversion algorithms" by Bonaiuto J, Rossiter HE, Meyer SS, Adams N, Little S, Callaghan MF, Dick F, Bestmann S, Barnes GR is now available in BioRxiv
June 2017 New paper on directional tDCS effects: modelling and validation
Our new paper on directional tDCS is online as preprint in bioRxiv now: "tDCS changes in motor excitability are specific to orientation of current flow" by Vishal Rawji, Matteo Ciocca, Andre Zacharia, David Soares, Dennis Truong, Marom Bikson, John Rothwell, and Sven Bestmann
April 2017 Archy will give the Brain Meeting at the WTCN on April 28th
Archy will talk about his work at the WTCN brain meeting on April 28th: "Computation and representation in decision making and emotion"
March 2017 Archy de Berker has successfully passed his viva!
Archy withstood a barrage of question from Tim Behrens and Michael Browing, and passed his Viva successfully!
April 2017 New opinion article published in Brain Stimulation
Our new opinion article "Are current flow models for transcranial electrical stimulation fit for purpose?" on current flow models and their utility is now published in Brain Stimulation.
Jan 2017 Congrats to Ana Saraiva for passing her viva and becoming a PhD!
Ana Saraiva is now a doctor - having passed the grilling questions by her examiners Essi Viding and Bryan Strange
Jan 2017 Sven will talk about Computational Neurostimulation in Dresden
Sven will speak about "'Understanding and predicting the behavioural consequences of brain stimulation with computational neurostimulation" at the Dept Psychology, Dresden University
Feb 2017 New paper accepted in JNNP on reinforcement, motor learning and stroke
Our paper "Reward and punishment enhance motor adaptation in stroke" by Quattrocchi, Greenwood, rothwe,, Galea and Bestmann has been accepted for publication in the Journal Neurology, Neurosurgery and Psychiatry
Jan 2017 New paper accepted in NeuroImage
Our paper "Using generative models to make probabilistic statements about hippocampal engagement in MEG" by Sofie Meyer, Holly Rossiter; Matthew Brookes, Mark W Woolrich, Sven Bestmann & Gareth R Barnes is now in press in NeuroImage
Dec 2016 New paper on choice hysteresis & computational neurostimulation accepted in eLife
"Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models" by Jimmy Bonaiuto, Archy de Berker and Sven Bestmann is now in press in eLife
Jan 2017 Sven and Jimmy will speak at NYC Neuromodulation 2017
Sven and Jimmy will talk about the spatial resolution of TMS and computational neurostimulation, respectively.
NYC Neuromodulation 2017 will focus on technologies and mechanism for advanced brain stimulation in areas that include transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial magnetic stimulation (TMS), high-definition transcranial direct current stimulation (HD-tDCS), electroconvulsive therapy (ECT), deep brain stimulation (DBS), and other emerging areas.
Oct 2016 New paper in PLoS Biology accepted
Louise's Marshall's paper "Pharmacological fingerprints of uncertainty" by Marshall M, Mathys C, Ruge D, de Berker A, Dayan P, Stephan KE, Bestmann S was just accepted in PLOS Biology
Sept 2016 Our paper on effort based decision making now published in JNeurosci
Our paper "Neural signatures of value comparison in human cingulate cortex during decisions requiring an effort-reward trade-off", with Miriam Klein-Flugge, Steve Kennerely, Karl Friston, and Sven Bestmann, has now been published in the Journal of Neuroscience. Find the open access paper here
Sept 2016 Sven will speak and chair at the TBS 2016 in Goettingen
Sven will chair the session on "Computational Neurostimulation" at the 2016 6th International Conference on Transcranial Brain Stimulation, and speak about the use of biophysical models and tDCS
New paper using cerebellar tDCS in perceptual speech decision in press now in JNP
Our paper "Cerebellar tDCS Dissociates the Timing of Perceptual Decisions from Perceptual Change in Speech", by Lametti D, Oostwoud Wijdenes L, Bonaiuto J, Bestmann S, Rothwell JC is now in press in the Journal of Neurophysiology
July 2016 Sven has presented our work on Computational Neurostimulation at CiNET, Osaka
Sven has presented our work on Computational Neurostimulation at the Centre for Information and Neural Networks, Osaka, Japan.
July 2016 Archy’s new paper “Acute stress selectively impairs learning to act” is now in press
Archy's paper "Acute stress selectively impairs learning to act", with Margot Tirole, Robb Rutledge, Gemma Cross, Ray Dolan, and Sven Bestmann, is now in press in Nature Scientific Reports
June 2016 New paper on neural basis of effort-reward trade-offs accepted in J Neurosci
Our paper "Neural signatures of value comparison in human cingulate cortex during decisions requiring an effort-reward trade-off" by Miriam Klein-Flügge, Steve Kennerley, Karl Friston, and Sven Bestmann is now in press in the Journal of Neuroscience
June 2016 Sven will present our work on high precision MEG to the StrangeLab in Madrid
Sven will visit Bryan Strange's StrangeLab at the Centre for Biomedical Technology in Madrid, to talk about our work on high precision MEG using head casts.
June 2016 Sven will give an online talk to Leo Cohen’s lab
Looking forward to our first online seminar, to Leo Cohen's group at NIH, on "Computational Neurostimulation in basic and translational neuroscience"
July 2016 Sven will present at the 31st International Congress for Psychology (ICP)
Sven will talk about "Using TMS to study the transformation from decisions to actions" in the Symposium on "Transcranial Magnetic Stimulation (TMS): a powerful tool for research in psychology and neuroscience", at the ICP in Yokohama, Japan
May 2016 Sven will speak at the Marr Club in Cambridge
Sven will speak at Benedetto de Martino's Marr Club in Cambridge, on "Towards a whole brain account of decisions for actions using high precision MEG"
march 2016 New paper on tdcs and value decisions in press in Scientific reports
Our paper "Selective alteration of human value decisions with medial frontal tDCS is predicted by changes in attractor dynamics" by Hammerer D, Bonaiuto J, Klein-Flugge M, Bikson M, BEstmann S is now in press in Scientific Reports
Feb 2016 Our paper The Evidence Information Service for evidence-based policy now in press
Our paper "The Evidence Information Service as a new platform for supporting evidence-based policy: A consultation of UK parliamentarians" by Lawrence N, Chambers J, Morrison S, Bestmann S, O'Grady G, Chambers CD and Kythreotis AP is now in press in Evidence & Policy
Feb 2016 New paper “Computations of uncertainty mediate acute stress responses in humans” accepted
Archy's paper "Computations of uncertainty mediate acute stress responses in humans" has been accepted in Nature Communications
Jan 2016 Sven and Inge are presenting at joint NTT-UCL meeting in Hon-Atsugi, Japan
Sven and Inge will present their work at the joint UCL - NTT Communication Sciences Laboratories meeting
Nov 2015 New paper accepted in Neuroimage, with Vincenzo Romei and Gregor Thut
Our new paper "Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS" by Romei, Bauer, Brooks, Economides, Penny, Thut, Driver, Bestmann, is now i press in NeuroImage
Nov 2015 New MSc students joining our lab
Welcome to Roeland Heerema, Jem Bhatt, and Jeff Inglis, who have joined our lab for their MSc research projects.
Nov 2015 Sven will speak at the “Updates in tDCS Clinical Trials” meeting in NYC
Oct 2015 Our four posters at this year’s SfN conference in chicago
438.18/AA11: A computational neurostimulation model of the nonlinear effects of tDCS
601.19/L41: A high resolution MEG study of predictive coding in action selection
611.19/Q11: Investigating the effect of current flow on cortical excitability using bipolar tDCS
711.08/V35: Cerebellar tdcs during speech perceptual learning dissociates the act of indicating perception from perceptual change
Sept 2015 sven has been elected as Vice chair of the young academy of europe
Sven was elected as new Vice Chair of the Young Academy of Europe at this year's Annual meeting of the YAE
Sept 2015 Alessandro’s new paper accepted in J Cogn Neurosci
New paper accepted in J Cogn Neurosci, on "The role of Dopamine in temporal uncertainty", by Alessandro Tomassini, Joe Galea, Diane Ruge, Will Penny, Sven Bestmann
June 2015 Sven is talking about Laminar-specific MEG at the OHBM15 meeting in Hawaii
as part of the symposium "Investigating Neuronal Computation in Cortical Laminae using Layer-Resolved fMRI & Electrophysiology" at OHBM15, Sven will speak about "Non-invasive electrophysiology of human cortical laminae"
June 2015 New paper by Jimmy on modelling nonlinear effects of tDCS
Jimmy's paper "Understanding the nonlinear physiological and behavioral effects of tDCS through computational neurostimulation " by Bonaiuto J, Bestmann S has been accepted in Prog Brain Res, as part of a special volume on "computational neurostimulation"
May 2015 Welcome to Rosy Southwell, who joined the lab for her MSc project
Rosy will conduct her MSc project with us, on the role of NA on perceptual learning
June 2015 Louise’s new paper has been accepted in Journal of Neuroscience
Louise's work with Paul Bays, "Evidence for optimal integration of visual feature representations across saccades", by Oostwoud Wijdenes L, Marshall L, & Bays PM., has been accepted in the Journal of Neuroscience!
May 2015 New review paper on action preparation accepted for publication in The Neuroscientist
Our paper "Transcranial magnetic stimulation: Decomposing the processes underlying action preparation" by Sven Bestmann and Julie Duque has been accepted for publication in The Neuroscientist
May 2015 Sven is talking about Computational Neurostimulation in Geneva
Sven will give the Brain and Cognition Seminar at Neuroscience Centre, University of Geneva
May 2015 New paper by Inge Volman accepted
Inge's paper "Testosterone biases the amygdala towards social threat approach" by Radke S, Volman I et al has been accepted in Science Advances
april 2015 sven is presenting at the 3rd North America Meeting on Brain Stimulation and Neuroimaging
sven will talk about Computational Neurostimulation at the 3rd North America Meeting on Brain Stimulation and Neuroimaging
april 2015 Sven will speak at the BNA 2015 meeting
As part of the symposium on non-invasive brain stimulation, Sven will talk about "Computational Neurostimulation"
March 2015 Our paper on effort discounting is now published in PLoS Comp Biol
Our new open access paper in PLoS Computational Biology can be found here
feb 2015 new paper “Binding space and time through action” accepted for publication
our paper "Binding space and time through action" by Binetti, Hagura, Fedipe, Tomassini, Walsh, Bestmann has been accepted in Proceedings of the Royal Society B
march 2015 Sven and Simon will speak at the 1st International Brain Stimulation Conference
Sven will present at the symposium "How to use Computational Models to Optimize Brain Stimulation", and Simon at the symposium on "Deep Brain Stimulation", at the 1st International Brain Stimulation Conference, Singapore
feb 2015 welcome to simon little, who has joined the lab on his wellcome fellowship
Simon has now started his prestigious Wellcome Trust Clinical Training Fellowship with us, and he will work on basic and translational aspects of beta oscillations
Feb 2015 Sven will speak at Trinity College Dublin on Improvements through neurostimulation
Looking forward to be speaking at Trinity College's Institute of Neuroscience on "Are there true Improvements with Neurostimulation?"
Feb 2015 Congratulations to Inge Volman for her Marie Curie Fellowship
Inge has received a prestigious Marie Curie Fellowship to come and work in our lab for two years. Congratulations!
Jan 2015 Sven to speak at this year’s NYC Neuromodulation meeting
Sven will talk about "How can we bridge between physiological and behavioural effects of tES?" at the NYC Neuromodulation meeting
Jan 2015 New paper accepted in PLoS Computational Biology
Miriam's paper "Behavioral Modeling of Human Choices Reveals Dissociable Effects of Physical Effort and Temporal Delay on Reward Devaluation" has been accepted in PLoS CB
Bestmannlab wishes a happy 2015 to everyone!
Happy new year to all firiends and colleagues!
Dec 2014 Programme for the Oxford Neuroscience conference is out
The list of speakers of the 2015 Magstim Neuroscience Conference in Oxford May 2015, organized by Vince Walsh, Charlie Stagg, and Sven Bestmann
new paper in Experimental Brain Research has been accepted for publication
Our paper "The uses and interpretations of the motor-evoked potential for understanding behaviour", by Sven Bestmann and John Krakauer, is now in press in Experimental Brain Research
Welcome to Sheena Waters!
Sheena has just joined our lab! She also just passed her PhD viva, examined by Heidi Johansen-Berg and Alex Leff.
Congrats to Simon Little for getting a Wellcome Trust Clinical Research Fellowship
We're looking forward to Simon joining our lab soon...
Our posters at SfN 2014
We're presenting 7 posters at SfN this year, find us at poster numbers 71.09/GG17, 84.02/NN3, 84.03/NN4, 562.03/UU88, 635.11/LL20, 644.17/RR29, 743.08/SS2
Oct 2014 New paper in Trends in Cognitive Sciences
Look out for our new paper, "Understanding the behavioural consequences of non-invasive brain stimulation", coming to you in Trends in Cognitive Sciences soon
Oct 2014 New paper accepted in MRM
New paper entitled "A novel coil array for combined TMS/fMRI experiments at 3T" accepted in Magnetic Resonance in Medicine
Sept 2014 New paper published “A Setup for Administering TMS During fMRI
Our paper "A Setup for Administering TMS to Medial and Lateral Cortical Areas During Whole-Brain fMRI Recording" has been published in J Clin Neurophysiol
Sept 2014 New PhD student Isobel Weinberg has joined the lab
We welcome Isobel Weinberg, who has joined the lab on a 4-year MB-PhD programme.
Motor Control & Rehabilitation A Collaborative Johns Hopkins University - UCL Meeting
Great JHU-UCL meeting coming up in Baltimore, with an exciting programme
Muddy Bhat & Nick Ward: “Imaging in Neurorehabilitation and Canonical Microcircuits”; Robert Hardwick & Pablo Celnik: “Motor Physiology and Learning Early After Stroke” ; Ricci Hannah & John Rothwell: “The Anisotropy of Motor Cortex Stimulation”; Aaron Wong & John Krakauer: “Abstract Kinematic Planning and Its Possible Relationship to Apraxia”; Naveed Ejaz & Jörn Diedrichsen: "Ipsilateral Representations of Motor Skill: Epi-Phenomenon or Functional Role?"; Amir Kheradmand & David Zee: “Cortical Control of Perception of Verticality”; James Bonaiuto & Sven Bestmann: "Computational Neurostimulation"; David Herzfield & Reza Shadmehr: "A Memory of Errors in Sensorimotor Learning"; David Huberdeau & Adrian Haith: “Procedural Versus Declarative Motor Memory”
august 2014 post-doc position available NOW!
We are looking for a Post-doc joining us to investigate decision signals in the human motor system, with a specific focus on neuroimaging, and in particular magnetoencephalography (MEG) and electroencephalography (EEG). Additional techniques may include behavioural, neuropharmacological, and neurostimulation techniques such as TMS or tDCS. The post is available from October 2014 (i.e. NOW) and is funded to June 2016 in the first instance. See details here: http://www.jobs.ac.uk/job/AJL234/research-associate/
august 2014 Archy’s new article coming out in Journal of Neuroscience
New Journal Club article "A role for the human substantia nigra in reinforcement learning" by Archy de Berker and Robb Rutledge coming out in Journal of Neuroscience soon
August 2014 New paper accepted in Journal of Cognitive Neuroscience
Our paper "The role of dopamine in motor flexibility" with Joe Galea has been accepted for publication in the Journal of Cognitive Neuroscience
July 2014 New Post-doc and PhD/RA position available
One Post-doc and one PhD/Ra position is available with Dr Kielan Yarrow at City University, on "Novel neurometric measures to discriminate models of speeded decision making", jointly with our lab.
July 2014 Sven elected to the Board of the Young Academy of Europe
Sven got elected to the Board of the Young Academy of Europe, as Chair of the Life Science domain
July 2014 New paper accepted in NeuroImage
Our new paper "Discrimination of cortical laminae using MEG", with Luzia Troebinger and Gareth Barnes, has been accepted for publication ini Neuroimage.
May 2014 Talk at the Amsterdam Brain & Cognition Centre
Sven will speak about "Decisions for Actions", hosted by Tobias Donner
May 2014 Magstim Neuroscience Conference in Oxford
This year's Magstim Neuroscience conference is approaching fast, organised by Vince Walsh, Charlie Stagg and Sven Bestmann. Find the programme here
April 2014 Miriam has passed her viva!
Congratulations to our former lab member Miriam Klein-Flugge, who passed her viva and is now a PhD, with Prof Vince Walsh and Dr Mark Walton being the examiners.
April 2014 New journal club article in Neurology
Graziella's journal club article "Possible role of the basal ganglia in poor reward sensitivity and apathy after stroke" in press in Neurology
March 2014 talk at Brain & Spine Institute in Paris
Sven will talk about "Motivation and Action" at the Motivation Brain Behaviour Unit
March 2014 New paper in J Clin Neurophys
"A setup for administering TMS to medial and lateral cortical areas during whole brain fMRI recording" by De Weijer AD, Sommer IEC, Bakker EJ, Bloemendaal M, Bakker CJ, Klomp DWJ, Bestmann S, Neggers SFW accepted in J Clin Neurophys
March 2014: Neurofinance meets neurorehab meeting in Vitznau
Sven spoke about "Motivation and Action"
March 2014: Sven to speak at the brain & spine institute, paris
Sven will give a talk entitled "Motivation and Action"
Nov 2013: NTT visit
Sven will visit NTT, Tokyo, Japan
Nov 2013: NYC Neuromodulation conference
Sven will speak at the 2013 NYC Neuromodulation conference
Frontiers Human Neuroscience publication
New paper "Predicting the behavioural impact of transcranial direct current stimulation: issues and limitations" by de Berker, Bikson, Bestmann accepted in Frontiers Human Neuroscience
New PhD students on the team
Louise Marshall and Archy de Berker are joining the lab as a PhD students!
New publication in Neuroimage
New paper "High Precision Anatomy for MEG" by Troebinger L, Lopez JL, Lutti A, Bradbury D, Bestmann S, Barnes G accepted for publication in Neuroimage
Sven to speak at Danish Research Centre
Sven to speak about action selection and decision making at the Danish Research Centre for Magnetic Resonance
Aalto TMS symposium Helsinki
Sven will speak at the Aalto TMS symposium in Helsinki on the 17th
New PhD student joins the team
Graziella Quattrocchi joined our Lab as a PhD student!
New lab rotation students
Louise Marshall and Archy de Berker have started their lab rotations!
Keynote lecture at British Association for Cognitive Neuroscience meeting
Sven to give the keynote lecture at this year's British Association for Cognitive Neuroscience meeting in Nottingham, on "Action selection"
New York Academy of Science article
New paper "Combined neurostimulation and neuroimaging in cognitive neuroscience: past, present and future" accepted for publication in Annals of the New York Academy of Science, by Bestmann S & Feredoes E
Transcranial Magnetic Stimulation Book Chapter
Book chapter "Noninvasive Brain Stimulation and Neuroimaging: Novel Ways of Assessing Causal Relationships in Brain Networks" by O'Shea, Thut and Bestmann, has been published in "Transcranial Magnetic Stimulation" of the Frontiers in Neuroscience Series, Eds. Miniussi, Paulus, Rossini.
Journal of Neuroscience Publication
Miriam's paper ""Variability of human cortico-spinal excitability tracks the state of action preparation" by Klein-Flugge M, Nobbs D, Pitcher J, Bestmann S has been accepted in the Journal of Neuroscience
Joe publishes in Journal of Neuroscience
Joe's new paper accepted in the Journal of Neuroscience: "Punishment induced behavioural and neurophysiological variability reveals dopamine-dependent selection of kinematic movement parameters" by Galea J, Ruge D, Buijink A, Bestmann S, Rothwell JC.
Departmental Christmas party!!!! Don't plan anything for the 15th!
Young Academy of Europe
Sven attends the 1st Annual meeting of the Young Academy of Europe
Journal of Cognitive Neuroscience publication
New paper entitled "Muscle and timing-specific functional connectivity between the dorsolateral prefrontal cortex and the primary motor cortex" accepted in Journal of Cognitive Neuroscience, by Hasan, Galea, Casula, Falkai, Bestmann, Rothwell.
New team member
Bastian Soehnchen from Maastricht University has joined our lab for 9 months
Reatreat time. This year its 3 days in the lovely Pyrenees mountains!!!!!!
Lecture in Nijmegen
Sven will give a lecture at the Donders Centre in Nijmegen, on "Mechanisms for turning decisions into actions"
Foundation of Human Social Behaviour seminar series
Sven will speak at the Foundation of Human Social Behaviour seminar series, University of Zurich, about "Mechanisms for turning decisions into actions"
Society for Neuroscience meeting in New Orleans
Sven will attend this year's Society for Neuroscience meeting in New Orleans. He will present Miriam's poster "Variability of cortico-spinal excitability tracks the preparatory state of human motor cortex"Poster number 890.15, MM3**, Wednesday 3-4pm
Sven to talk at Sao Paulo Symposium
Sven to give two lectures at the III International Symposium on Neuromodulation, in Sao Paulo, Brazil.